LABORATORY

International Screening Limits

The National Horseracing Authority wishes to advise that the International Federation of Horseracing Authorities (IFHA) has approved International Screening Limits (ISLs) to be applied in the control of therapeutic substances and also Residue Limits to control certain contaminants and environmental substances. These ISLs and International Residue Limits form part of the International Agreement on Breeding, Racing and Wagering. The NHA, as the South African member of the IFHA, has agreed to adopt selected ISLs. In accordance with this, the NHA is currently applying these in its screening program while employing the IFHA’s definition which is as follows:

“The ISL is the urine or plasma concentration adopted for the screening of a specified therapeutic prohibited substance; it is derived from administration studies followed by a risk analysis consisting of two components: a risk assessment (evaluation of the effect of the substance and factors related to its control) and a risk management (decision step for harmonisation). ISLs and International Residue Limits are harmonised detection limits agreed following input by international consensus and are conveyed by instruction from racing authorities to their laboratories. These limits are simply the detection limits to be used by the laboratories when screening for certain therapeutic substances as instructed by the authorities; they are not international thresholds. When the screening procedure indicates the limit, in either urine or plasma, has been exceeded, all that is required is qualitative confirmatory analysis (usually by mass spectrometry) to confirm the presence or absence of the prohibited substance. Quantification is not required.”

a

Controlled by 4-methylaminoantipyrine

b

Controlled by 3'-hydroxylidocaine

c

Controlled by 3'-hydroxymepivacaine

d

Controlled by ambroxol

e

Controlled by 2-(1-hydroxyethyl)promazine sulphoxide)

f

Controlled by 3'-hydroxydetomidine

g

Controlled by 5-hydroxydantrolene

h

Controlled by 3’-Hydroxydetomidine